Notice & Notes:
- This Safety Data Sheet (SDS) is compiled by AutoChemSDS in strict accordance with the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (GHS Rev. 11, ST/SG/AC.10/30/Rev.11 Annex 4). Data is curated from open authoritative scientific sources (PubChem, HSDB, CAMEO, ECHA, NIOSH, WHO/ILO).
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[(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate Safety Data Sheet
SECTION 1: Identification of the Substance/Mixture and of the Company
CAS Registry Number: 51-55-8
European Community (EC) Number: Not available
Molecular Formula: C₁₇H₂₃NO₃
Molecular Weight: 289.4 g/mol g/mol
Synonyms: RefChem:1092872, Npc209773, ATROPINE, dl-Hyoscyamine
Recommended Use: Industrial chemical manufacturing, laboratory reagent, solvent, and scientific research.
Restrictions on Use: Avoid unauthorized domestic consumer use or release into unventilated enclosed spaces.
SECTION 2: Hazard(s) Identification
Not classified as hazardous according to GHS criteria.
Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source, is a potential dust explosion hazard.
SECTION 3: Composition / Information on Ingredients
3.1 Substances
| Component | Chemical Name | EC Number | Common / Synonyms | Concentration (%) | CAS Number | Formula | Molecular Weight |
|---|---|---|---|---|---|---|---|
| Main Substance | [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate | Not available | RefChem:1092872, Npc209773, ATROPINE, dl-Hyoscyamine | ≥ 99.0 % | 51-55-8 | C₁₇H₂₃NO₃ | 289.4 g/mol |
3.2 Mixtures
SECTION 4: First-Aid Measures
4.1 Description of Necessary First-Aid Measures
Inhalation: Move victim to fresh air. If breathing is irregular or stopped, administer artificial respiration. Keep victim warm and at rest. If symptoms develop, seek medical advice.
Skin Contact: Immediately remove contaminated clothing. Rinse skin thoroughly with plenty of running water for at least 15 minutes. Consult a physician if irritation develops.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids. Remove contact lenses if present and easy to do. Continue rinsing. Seek medical attention (consult an ophthalmologist).
Ingestion: Never give anything by mouth to an unconscious person. Rinse mouth thoroughly with water. Do NOT induce vomiting unless directed by medical personnel. If feeling unwell, seek medical advice.
Personal Protective Equipment for First-Aiders: Responders must wear appropriate personal protective equipment (PPE) suitable for the chemical hazard. Do not enter hazardous atmospheres without appropriate respiratory protection (e.g. positive-pressure SCBA).
4.2 Most Important Symptoms/Effects, Acute and Delayed
No specific acute or delayed symptoms described under normal handling conditions.
4.3 Indication of Immediate Medical Attention and Special Treatment Needed
Treat symptomatically and supportively. Monitor vital signs and respiratory functions. No specific antidote known.
SECTION 5: Fire-Fighting Measures
Suitable Extinguishing Media: Water spray, Dry chemical powder, Carbon dioxide (CO2), Alcohol-resistant foam, Dry sand.
Unsuitable Extinguishing Media: None identified. Use media appropriate for surrounding fire.
Hazardous combustion products formed under fire conditions: Carbon oxides (CO, CO2), Nitrogen oxides (NOx).
Hazardous Combustion Products: Carbon oxides (CO, CO2), Nitrogen oxides (NOx).
Isolate fire area and deny unnecessary entry. Water spray may be used to keep fire-exposed containers cool until well after fire is extinguished. Firefighters must wear self-contained breathing apparatus (SCBA) in positive pressure mode and full protective turnout gear (EN 469 / NFPA 1971).
SECTION 6: Accidental Release Measures
6.1 Personal Precautions, Protective Equipment and Emergency Procedures
For Non-Emergency Personnel: Ensure adequate ventilation. Evacuate unnecessary personnel to safe areas. Avoid breathing vapors, mist, or dust. Avoid contact with skin, eyes, and clothing. Wear appropriate personal protective equipment (see Section 8).
For Emergency Responders: Wear appropriate personal protective equipment including respiratory protection, chemical safety goggles, and protective clothing.
6.2 Environmental Precautions
Prevent further leakage or spillage if safe to do so. Prevent spilled material from entering drains, sewers, waterways, and soil. Inform environmental authorities if spillage causes environmental contamination.
6.3 Methods and Materials for Containment and Cleaning Up
Small Spill Clean-up: Collect spilled material using clean, non-sparking tools into clean, dry containers and remove from spill area.
Large Spill Clean-up: Cover with plastic sheet or canvas to reduce dispersion, keep dry, and prevent rain exposure. Under expert guidance, collect into clean, dry containers and remove from spill area.
Prevention of Secondary Hazards: Prevent dust and aerosol formation in air;
SECTION 7: Handling and Storage
7.1 Precautions for Safe Handling
Use only in well-ventilated areas. Avoid contact with skin, eyes, and clothing. Avoid breathing vapors, mist, or dust. Keep container tightly closed. Wash hands thoroughly with soap and water after handling.
Hygiene Measures: Prohibit eating, drinking, and smoking in work and storage areas. Wash hands thoroughly with soap and water after handling and before breaks. Remove contaminated clothing and protective equipment before entering eating areas.
7.2 Conditions for Safe Storage, including Any Incompatibilities
Store in original tightly closed container in a cool, dry, and well-ventilated area away from direct sunlight, heat, moisture, and incompatible materials. Keep container tightly closed.
Incompatible Materials: Strong oxidizing agents.
Packaging Recommendations: Keep only in original manufacturer-approved container. Ensure container material is compatible with the substance and certified for dangerous goods transport (UN-approved packaging). Keep container tightly closed.
SECTION 8: Exposure Controls / Personal Protection
8.1 Control Parameters (Occupational Exposure Limit Values)
| Standard / Agency | Limit Type | Value | Remarks / Notation |
|---|---|---|---|
| US ACGIH | TLV-TWA | Not established | None |
| US ACGIH | TLV-STEL | Not established | None |
| US ACGIH | TLV-C | Not established | None |
Biological Limit Values: No biological exposure determinants (ACGIH BEIs) established.
8.2 Appropriate Engineering Controls
Provide adequate local exhaust ventilation and general ventilation to maintain airborne concentrations below occupational exposure limits. Emergency eyewash fountains and safety showers must be readily accessible in the immediate work area.
8.3 Individual Protection Measures (Personal Protective Equipment - PPE)
Eye/Face Protection: Wear tightly fitting safety goggles and face shield conforming to EN 166 or ANSI Z87.1. Ensure emergency eyewash facilities and safety showers are available.
Hand Protection: Wear chemical-resistant, impermeable protective gloves conforming to EN 374 / ANSI/ISEA 105. Glove suitability and breakthrough time depend on workplace usage conditions; consult glove manufacturer for specific chemical resistance data. Inspect gloves prior to use.
Skin and Body Protection: Wear appropriate protective clothing to minimize skin contact. Protective equipment must be selected based on the concentration and amount of the hazardous substance at the workplace.
Respiratory Protection: Where risk assessment shows air-purifying respirators are appropriate, use a respirator with approved filter cartridge (e.g. EN 14387 / NIOSH approved) suitable for the chemical hazard. If exposure limits are exceeded or in emergency/confined space scenarios, wear positive-pressure supplied-air respirator or SCBA.
Thermal Hazards: Wear appropriate thermal insulated protective clothing when handling refrigerated, cryogenic, or high-temperature materials.
SECTION 9: Physical and Chemical Properties
9.1 Basic Physical and Chemical Properties
| Property | Value / Observation |
|---|---|
| 1. Physical state | Solid |
| 2. Colour | No data available |
| 3. Odour | No data available |
| 4. Melting point / freezing point | No data available |
| 5. Boiling point or initial boiling point and boiling range | No data available |
| 6. Flammability | Non-flammable / Not classified |
| 7. Lower and upper explosion limit / flammability limit | Lower: Not applicable, Upper: Not applicable |
| 8. Flash point | Not applicable (non-flammable) |
| 9. Auto-ignition temperature | No data available |
| 10. Decomposition temperature | No data available |
| 11. pH | No data available |
| 12. Kinematic viscosity | Not applicable (solid) |
| 13. Solubility | >43.4 [ug/mL] (The mean of the results at pH 7.4) |
| 14. Partition coefficient: n-octanol/water (log value) | No data available |
| 15. Vapour pressure | No data available |
| 16. Density and/or relative density | No data available |
| 17. Relative vapour density | Not applicable (solid) |
| 18. Particle characteristics | No data available (solid particle size not specified) |
9.2 Other Information
| Safety Characteristic | Value / Result |
|---|---|
| Evaporation rate | No data available |
| Heat of combustion | No data available |
| Critical temperature and pressure | No data available |
| Acid dissociation constant (pKa) | 9.84 |
| Odour threshold | No data available |
SECTION 10: Stability and Reactivity
10.1 Reactivity: No dangerous reaction known under recommended conditions of storage and handling.
10.2 Chemical Stability: Stable under recommended storage and handling conditions.
10.3 Possibility of Hazardous Reactions: Hazardous polymerization will not occur. Exothermic or hazardous reactions possible with incompatible materials.
10.4 Conditions to Avoid: Excess heat, direct sunlight, and incompatible materials.
10.5 Incompatible Materials: Strong oxidizing agents.
10.6 Hazardous Decomposition Products: Carbon oxides (CO, CO2), Nitrogen oxides (NOx).
SECTION 11: Toxicological Information
11.1 Information on Hazard Classes / Toxicological Effects
Acute Toxicity: Based on available data, the classification criteria are not met.
Skin Corrosion / Irritation: Based on available data, the classification criteria are not met.
Serious Eye Damage / Irritation: Based on available data, the classification criteria are not met.
Respiratory or Skin Sensitization: Based on available data, the classification criteria are not met.
Germ Cell Mutagenicity: Based on available data, the classification criteria are not met.
Carcinogenicity: Based on available data, the classification criteria are not met.
Reproductive Toxicity: Based on available data, the classification criteria are not met.
STOT - Single Exposure: Based on available data, the classification criteria are not met.
STOT - Repeated Exposure: Based on available data, the classification criteria are not met.
Aspiration Hazard: Based on available data, the classification criteria are not met.
11.2 Information on Other Hazards
Endocrine Disrupting Properties: No specific data available regarding endocrine disrupting properties for human health.
11.3 Symptoms Related to Characteristics
No specific acute or delayed symptoms described under normal handling conditions.
11.4 Delayed and Immediate Effects from Short and Long-Term Exposure
Immediate and delayed effects after short and long-term exposure are consistent with GHS hazard classifications (see Section 2).
11.5 Interactive Effects
No interactive effects data available.
SECTION 12: Ecological Information
12.1 Toxicity (Aquatic and Terrestrial): No ecotoxicity test data available.
12.2 Persistence and Degradability: No biodegradation test data available.
12.3 Bioaccumulative Potential: No bioaccumulation experimental data available.
12.4 Mobility in Soil: No soil mobility experimental data available.
12.5 Results of PBT and vPvB Assessment: No specific PBT or vPvB assessment data available.
12.6 Endocrine Disrupting Properties: No specific data available regarding endocrine disrupting properties in the environment.
12.7 Other Adverse Effects: No other adverse environmental effects (such as ozone depletion potential or global warming potential) are known from available data.
SECTION 13: Disposal Considerations
13.1 Disposal Methods
Waste Treatment and Residues: Avoid or minimize waste generation. Incinerate in an approved, licensed chemical incinerator equipped with an afterburner and scrubber. Dispose of surplus and non-recyclable solutions via a licensed waste disposal contractor in compliance with national and regional environmental laws. Do NOT dispose of waste into sewers or waterways.
Contaminated Packaging: Empty containers retain product residue. Do NOT cut, puncture, or weld empty containers. Dispose of as hazardous waste or return to supplier in accordance with environmental regulations.
Disposal Precautions: Wear appropriate PPE (see Section 8). Controlled high-temperature incineration is recommended.
SECTION 14: Transport Information
Transport in closed, upright, secured containers. Ensure vehicle/cargo hold is well-ventilated. Observe applicable dangerous goods transport regulations (ADR, RID, ADN, IMDG, ICAO/IATA).
Not applicable. Transported in packaged form; not intended for bulk maritime transport under IMO instruments (MARPOL Annex II / IBC Code).
SECTION 15: Regulatory Information
15.1 Safety, Health and Environmental Regulations Specific for the Product in Question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| [(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate | RefChem:1092872, Npc209773, ATROPINE, dl-Hyoscyamine | 51-55-8 | Not available |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Not listed | ||
| EC Inventory | Not listed | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed (Active) | ||
| China Catalog of Hazardous chemicals 2015 | Not listed | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Not listed | ||
| Australian Inventory of Industrial Chemicals (AIIC) | Not listed | ||
International Environmental Conventions:
• Montreal Protocol (Ozone Depleting Substances): Not listed
• Stockholm Convention (Persistent Organic Pollutants - POPs): Not listed
• Rotterdam Convention (Prior Informed Consent - PIC): Not listed
• Minamata Convention on Mercury: Not listed
15.2 Chemical Safety Assessment
No Chemical Safety Assessment (CSA) has been carried out for this substance/mixture by the supplier (No authoritative CSA data source available). In accordance with UN GHS Rev. 11 (ST/SG/AC.10/30/Rev.11, Annex 4, Section A4.3.15), a formal Chemical Safety Assessment is not required under the harmonized UN GHS framework unless mandated by specific national or regional regulations; users should verify applicable local regulatory obligations prior to handling or use.
SECTION 16: Other Information
Version 2.0 (UN GHS Rev. 11 Annex 4 Compliant)
Revision Date: 2026-10-27
Indication of changes: Fully aligned with United Nations GHS Rev. 11 standard guidelines and sub-headings.
- PubChem [https://pubchem.ncbi.nlm.nih.gov]
- Sanford-Burnham Center for Chemical Genomics [https://pubchem.ncbi.nlm.nih.gov/bioassay/1996#section=Data-Table]
- ChEMBL [https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL517712]
- IARC Monographs on the Identification of Carcinogenic Hazards to Humans
- United Nations: Globally Harmonized System of Classification and Labelling of Chemicals (GHS), 11th revised edition (ST/SG/AC.10/30/Rev.11)
- National Center for Biotechnology Information (NCBI): PubChem Compound Database
- Hazardous Substances Data Bank (HSDB), National Library of Medicine
- CAMEO Chemicals Database, NOAA
- European Chemicals Agency (ECHA) Registered Substances Information
- World Health Organization (WHO) / International Labour Organization (ILO): International Chemical Safety Cards (ICSCs)
- National Institute for Occupational Safety and Health (NIOSH): Pocket Guide to Chemical Hazards
ACGIH: American Conference of Governmental Industrial Hygienists
ADN: European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways
ADR: Agreement concerning the International Carriage of Dangerous Goods by Road
AIIC: Australian Inventory of Industrial Chemicals
CAS: Chemical Abstracts Service
EC50: Half maximal effective concentration
EINECS: European Inventory of Existing Commercial Chemical Substances
GHS: Globally Harmonized System of Classification and Labelling of Chemicals (Eleventh revised edition)
IARC: International Agency for Research on Cancer
IATA: International Air Transport Association
IBC Code: International Code for the Construction and Equipment of Ships carrying Dangerous Chemicals in Bulk
ICAO: International Civil Aviation Organization
IECSC: Inventory of Existing Chemical Substances in China
IMDG: International Maritime Dangerous Goods Code
LC50: Lethal concentration, 50 percent
LD50: Lethal dose, 50 percent
LEL / UEL: Lower Explosive Limit / Upper Explosive Limit
MARPOL: International Convention for the Prevention of Pollution from Ships
NIOSH: National Institute for Occupational Safety and Health
NZIoC: New Zealand Inventory of Chemicals
OSHA: Occupational Safety and Health Administration
PBT: Persistent, Bioaccumulative and Toxic
PEL: Permissible Exposure Limit
REL: Recommended Exposure Limit
RID: Regulations concerning the International Carriage of Dangerous Goods by Rail
SCBA: Self-Contained Breathing Apparatus
STEL: Short Term Exposure Limit
STOT: Specific Target Organ Toxicity
TLV: Threshold Limit Value
TSCA: Toxic Substances Control Act
TWA: Time Weighted Average
UN: United Nations Recommendations on the Transport of Dangerous Goods
vPvB: Very Persistent and Very Bioaccumulative
Workers must receive documented training on chemical handling hazards, proper PPE usage, emergency response, and firefighting prior to handling this chemical.
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information, and belief at the date of its publication. The information given is designed only as guidance for safe handling, use, processing, storage, transportation, disposal, and release and is not to be considered a warranty or quality specification. AutoChemSDS assumes no legal liability for any damages resulting from the handling or use of the designated product.