p-Chloronitrobenzene Safety Data Sheet

3.1 Substances

3.2 Mixtures

4.1 Description of Necessary First-Aid Measures

4.2 Most Important Symptoms/Effects, Acute and Delayed

The most important known symptoms and effects include: Toxic if swallowed; Toxic in contact with skin; Toxic if inhaled; Suspected of causing genetic defects; Suspected of causing cancer; May causes damage to organs through prolonged or repeated exposure; Toxic to aquatic life with long lasting effects.

4.3 Indication of Immediate Medical Attention and Special Treatment Needed

Treat symptomatically and supportively. Monitor vital signs and respiratory functions. No specific antidote known.

6.1 Personal Precautions, Protective Equipment and Emergency Procedures

For Non-Emergency Personnel: Ensure adequate ventilation. Evacuate unnecessary personnel to safe areas. Avoid breathing vapors, mist, or dust. Avoid contact with skin, eyes, and clothing. Wear appropriate personal protective equipment (see Section 8).

For Emergency Responders: Wear appropriate personal protective equipment including respiratory protection, chemical safety goggles, and protective clothing.

6.2 Environmental Precautions

Prevent further leakage or spillage if safe to do so. Prevent spilled material from entering drains, sewers, waterways, and soil. Inform environmental authorities if spillage causes environmental contamination.

6.3 Methods and Materials for Containment and Cleaning Up

Small Spill Clean-up: Collect spilled material using clean, non-sparking tools into clean, dry containers and remove from spill area.

Large Spill Clean-up: Cover with plastic sheet or canvas to reduce dispersion, keep dry, and prevent rain exposure. Under expert guidance, collect into clean, dry containers and remove from spill area.

Prevention of Secondary Hazards: Prevent dust and aerosol formation in air;

7.1 Precautions for Safe Handling

Use only in well-ventilated areas. Avoid contact with skin, eyes, and clothing. Avoid breathing vapors, mist, or dust. Keep container tightly closed. Wash hands thoroughly with soap and water after handling.

Hygiene Measures: Prohibit eating, drinking, and smoking in work and storage areas. Wash hands thoroughly with soap and water after handling and before breaks. Remove contaminated clothing and protective equipment before entering eating areas.

7.2 Conditions for Safe Storage, including Any Incompatibilities

Store in original tightly closed container in a cool, dry, and well-ventilated area away from direct sunlight, heat, moisture, and incompatible materials. Keep container tightly closed.

Incompatible Materials: Strong oxidizing agents.

Packaging Recommendations: Keep only in original manufacturer-approved container. Ensure container material is compatible with the substance and certified for dangerous goods transport (UN-approved packaging). Keep container tightly closed.

8.1 Control Parameters (Occupational Exposure Limit Values)

Biological Limit Values: No biological exposure determinants (ACGIH BEIs) established.

8.2 Appropriate Engineering Controls

Provide adequate local exhaust ventilation and general ventilation to maintain airborne concentrations below occupational exposure limits. Emergency eyewash fountains and safety showers must be readily accessible in the immediate work area.

8.3 Individual Protection Measures (Personal Protective Equipment - PPE)

9.1 Basic Physical and Chemical Properties

9.2 Other Information

10.1 Reactivity: No dangerous reaction known under recommended conditions of storage and handling.

10.2 Chemical Stability: Stable under recommended storage and handling conditions.

10.3 Possibility of Hazardous Reactions: Hazardous polymerization will not occur. Exothermic or hazardous reactions possible with incompatible materials.

10.4 Conditions to Avoid: Excess heat, direct sunlight, and incompatible materials.

10.5 Incompatible Materials: Strong oxidizing agents.

10.6 Hazardous Decomposition Products: Carbon oxides (CO, CO2), Hydrogen chloride gas (HCl), Nitrogen oxides (NOx).

11.1 Information on Hazard Classes / Toxicological Effects

11.2 Information on Other Hazards

Endocrine Disrupting Properties: No specific data available regarding endocrine disrupting properties for human health.

11.3 Symptoms Related to Characteristics

The most important known symptoms and effects include: Toxic if swallowed; Toxic in contact with skin; Toxic if inhaled; Suspected of causing genetic defects; Suspected of causing cancer; May causes damage to organs through prolonged or repeated exposure; Toxic to aquatic life with long lasting effects.

11.4 Delayed and Immediate Effects from Short and Long-Term Exposure

Immediate and delayed effects after short and long-term exposure are consistent with GHS hazard classifications (see Section 2).

11.5 Interactive Effects

No interactive effects data available.

12.1 Toxicity (Aquatic and Terrestrial): LC50 Leuciscus idus /(Ide)/ 2.0 mg/L for 48 hr /Conditions of bioassay not specified in source examined/

12.2 Persistence and Degradability: AEROBIC: 10 ug/mL 1-chloro-4-nitrobenzene inoculated with a mixed culture of microorganisms in soil was observed to be resistant to biodegradation (significant ring cleavage, as measured by UV absorbance, was not detected after 64 days)(1). 1-Chloro-4-nitrobenzene , present at 100 mg/L, reached 0 percent of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(2).

12.3 Bioaccumulative Potential: Carp exposed to solutions containing 0.15 ppm 1-chloro-4-nitrobenzene for 8 weeks had BCF values ranging from 5.8-20.9, and carp exposed to solutions containing 0.015 ppm 1-chloro-4-nitrobenzene had BCF values ranging from 7.5-18.1(1). According to a classification scheme(2), these BCF values suggest bioconcentration in aquatic organisms is low(SRC).

12.4 Mobility in Soil: Using a structure estimation method based on molecular connectivity indices(1), the Koc of 1-chloro-4-nitrobenzene can be estimated to be 310(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1-chloro-4-nitrobenzene is expected to have moderate mobility in soil(SRC).

12.5 Results of PBT and vPvB Assessment: No specific PBT or vPvB assessment data available.

12.6 Endocrine Disrupting Properties: No specific data available regarding endocrine disrupting properties in the environment.

12.7 Other Adverse Effects: Avoid release to the environment. Toxic or very toxic to aquatic life.

13.1 Disposal Methods

Waste Treatment and Residues: Avoid or minimize waste generation. Incinerate in an approved, licensed chemical incinerator equipped with an afterburner and scrubber. Dispose of surplus and non-recyclable solutions via a licensed waste disposal contractor in compliance with national and regional environmental laws. Do NOT dispose of waste into sewers or waterways.

Contaminated Packaging: Empty containers retain product residue. Do NOT cut, puncture, or weld empty containers. Dispose of as hazardous waste or return to supplier in accordance with environmental regulations.

Disposal Precautions: Wear appropriate PPE (see Section 8). Controlled high-temperature incineration is recommended.

15.1 Safety, Health and Environmental Regulations Specific for the Product in Question

15.2 Chemical Safety Assessment

No site-specific or registration-dossier Chemical Safety Assessment (CSA) / Chemical Safety Report (CSR) has been carried out for this substance by the SDS compiler. The hazard and safety classifications presented in this SDS are derived from publicly available regulatory assessment records (Authoritative Data Source(s): ILO-WHO International Chemical Safety Cards (ICSCs); European Chemicals Agency (ECHA); Hazardous Chemical Information System (HCIS), Safe Work Australia; NITE-CMC; Regulation (EC) No 1272/2008 of the European Parliament and of the Council). In accordance with UN GHS Rev. 11 (ST/SG/AC.10/30/Rev.11, Annex 4, Section A4.3.15), users should verify and comply with applicable national or regional chemical safety assessment obligations prior to use.